Comparative Effectiveness of Compassion-Focused Therapy (CFT) and Metacognitive Therapy (MCT) on Experiential Avoidance and Rumination in Women with Major Depressive Disorder
Keywords:
Compassion-Focused Therapy, Metacognitive Therapy, Experiential Avoidance, Rumination, Major Depressive Disorder, WomenAbstract
Purpose: This study aimed to compare the effectiveness of Compassion-Focused Therapy (CFT) and Metacognitive Therapy (MCT) in reducing experiential avoidance and rumination among women diagnosed with major depressive disorder.
Methods and Materials: This quasi-experimental study employed a pretest–posttest design with a three-month follow-up and a control group. The statistical population consisted of women with major depressive disorder who attended comprehensive health service centers and psychological clinics in Tabriz, Iran, in 2026. Using purposive sampling, 45 eligible women diagnosed through the Structured Clinical Interview for DSM Disorders (SCID) were selected and randomly assigned to three groups of 15 participants: CFT, MCT, and control. Data were collected using the Beck Depression Inventory-II (BDI-II), Acceptance and Action Questionnaire-II (AAQ-II), and Ruminative Responses Scale (RRS). The CFT group received eight 90-minute sessions of compassion-focused therapy, while the MCT group received eight 90-minute sessions of metacognitive therapy. The control group remained on a waiting list. Data were analyzed using repeated-measures analysis of variance and Bonferroni post hoc tests at a significance level of .05.
Findings: Repeated-measures analysis showed significant effects of time, group, and the time × group interaction on both experiential avoidance and rumination. Bonferroni post hoc comparisons indicated that both CFT and MCT produced significantly greater reductions in experiential avoidance and rumination than the control condition at posttest and three-month follow-up. Moreover, comparisons between the two intervention groups demonstrated that CFT resulted in significantly greater and more sustained reductions in both experiential avoidance and rumination than MCT, indicating superior maintenance of therapeutic gains over the follow-up period.
Conclusion: Both CFT and MCT appear effective for addressing cognitive and emotional processes associated with major depressive disorder; however, CFT demonstrated greater and more persistent effects on experiential avoidance and rumination. By targeting shame, self-criticism, and self-blame while cultivating self-compassion and internal safeness, CFT may offer particular advantages for women with major depressive disorder and may be considered a potentially preferable intervention for achieving sustained psychological improvement.
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References
Alves, M. I., & Neto, D. D. (2026). Guilt in Bereavement: The Role of Experiential Avoidance and Rumination. Death Studies, 50(1-8). https://doi.org/10.1080/07481187.2026.2704579
Bemani, S., Barazandeh, A., Khajavi, M., Samadifard, N., & Esmaeilzadeh, L. (2025). Effectiveness of Compassion Focused Therapy on Self-Blaming and Depressive Symptoms of Depressed Bullied Adolescents. Journal of Research in Psychopathology, 6(1), 45-53. https://doi.org/10.61838/kman.jayps.6.5.5
Brown, N., & Ashcroft, K. (2025). The Effectiveness of Compassion Focused Therapy for the Three Flows of Compassion, Self-Criticism, and Shame in Clinical Populations: A Systematic Review. Behavioral Sciences, 15(8), 1031. https://doi.org/10.3390/bs15081031
Cai, W., Jing, X., Wen, Y., Sun, S., Li, G., Liu, P., & Liu, Z. (2026). Neural Mechanisms of Rumination Subtypes in Adolescent Major Depressive Disorder Based on Large-Scale Brain Network Analysis. Journal of affective disorders, 392, 121217. https://doi.org/10.1016/j.jad.2026.121217
Conradi, H. S., Nguyen, T., Lawal, O. A., & Carlson, L. E. (2025). Mindfulness and Psychosocial Symptoms in People with Cancer: Testing Rumination and Experiential Avoidance as Mediators, and Sex as a Moderator. Global Advances in Integrative Medicine and Health, 14, 27536130251367051. https://doi.org/10.1177/27536130251367051
Dabbaghha, Z., & Mollazadeh, A. (2025). The Effectiveness of Compassion-Based Therapy on Rumination and Concern in Patients with Type I Diabetes. Iranian Journal of Diabetes and Obesity, 17(2), 110-118. https://doi.org/10.18502/ijdo.v17i2.18849
Emmanuel, C. I., & Jide-Ojo, O. T. (2026). Childhood Trauma, Rumination, Emotional Avoidance, Social Isolation, and Psychological Inflexibility as Predictors of PTSD Symptoms among Trauma Survivors in Onitsha, Anambra State, Nigeria. Islamic University Journal of Social Sciences, 5(4), 345-357.
Hallford, D., & Moradi, A. (2026). Distress Intolerance and Worry and Rumination: Analysis of the Mediating Role of Experiential Avoidance and Emotional Contrast Avoidance. Journal of affective disorders, 390, 112-120.
He, H., Cathomas, F., Parise, L. F., David, E., Rizk, M., Hawkins, K., & Murrough, J. W. (2026). Major Depressive Disorder Shares Systemic Immune Signatures and Potential Therapeutic Targets with Inflammatory Skin Diseases. Molecular Psychiatry, 31(5), 2498-2508. https://doi.org/10.1038/s41380-025-03383-5
Heydari, S., & Dasht Bozorgi, Z. (2026). Healing through Self-Kindness: Efficacy of Compassion-Based Intervention in Enhancing Self-Esteem, Reducing Rumination, and Alleviating Loneliness in Primiparous Women with Postpartum Depression. Journal of Health Psychology, 31(5), 13591053261442607. https://doi.org/10.1177/13591053261442607
Hurtig Parkrud, H., Anderberg, M., Vestin, M., & Dennhag, I. (2026). Young People's Experiences of Compassion-Focused Group Therapy: A Reflexive Thematic Analysis. Psychotherapy Research, 36(7), 1-12. https://doi.org/10.1080/10503307.2026.2625272
Ito, Y., Kawai Iwasaki, Y., Asano, K., Toshimitsu, M., Sakakibara, E., Yumura, H., & Nishi, D. (2026). Guided Internet-Delivered Compassion-Focused Therapy for Women with Recurrent Pregnancy Loss: A Protocol of a Randomized Controlled Trial. Psychiatry and Clinical Neurosciences Reports, 5(1), e70293. https://doi.org/10.1002/pcn5.70293
Kreis, M., Arens, E. A., Hofmann, S. G., & Stangier, U. (2025). Compassion-Focused Therapy und Metta-basierte Therapie: Ein systematisches Review. Verhaltenstherapie, 35(2-3), 78-90. https://doi.org/10.1159/000542737
Lala, O. H., & Odedokun, S. A. (2025). Criminal Behaviour Tendencies: Concepts, Prevalence, Consequences and Compassion-Focused Therapy. NIU Journal of Legal Studies, 11(1), 17-26. https://doi.org/10.58709/niujls.v11i1.2131
Lind, B. M., & Gibb, B. E. (2026). Co-Rumination with Peers Predicts Risk for Depression in Offspring of Mothers with Major Depressive Disorder. Research on Child and Adolescent Psychopathology, 54(4), 91. https://doi.org/10.1007/s10802-026-01486-3
Marques, C. C., Sayal, A., Palmeira, L., Goss, K., Correia, R., Castilho, P., & Castelo-Branco, M. (2025). Therapeutic Benefits of a 16-Week Compassion Focused Therapy for Overeating Are Associated with Positive Autonomic Changes and Putamen Responses. International Journal of Eating Disorders, 58(8), 1499-1512. https://doi.org/10.1002/eat.24456
Marx, W., Penninx, B. W., Solmi, M., Furukawa, T. A., Firth, J., Carvalho, A. F., & Berk, M. (2023). Major Depressive Disorder. Nature Reviews Disease Primers, 9(1), 44. https://doi.org/10.1038/s41572-023-00454-1
Mazza, S., Kieran, M., Tonta, K. E., Erceg-Hurn, D. M., Swan, A., Campbell, B. N., & McEvoy, P. M. (2025). Online Group Metacognitive Therapy for Repetitive Negative Thinking: A Pilot Study. Behavior therapy, 56(2), 320-335. https://doi.org/10.1016/j.beth.2025.04.004
Momeni, F., Bavi, S., Sevari, K., Saadi, Z. E., & Khalafi, A. (2025). Compassion-Focused Therapy for Bulimia Nervosa in Women: Effects on Rumination and Early Maladaptive Schemas. Iranian Journal of Diabetes and Obesity, 17(3), 201-210. https://doi.org/10.18502/ijdo.v18i1.21061
Normann, N., & Morina, N. (2018). The Efficacy of Metacognitive Therapy: A Systematic Review and Meta-Analysis. Frontiers in psychology, 9, 2211. https://doi.org/10.3389/fpsyg.2018.02211
Rawat, A., Sangroula, N., Khan, A., Faisal, S., Chand, A., Yousaf, R. A., & Yousaf, H. (2023). Comparison of Metacognitive Therapy versus Cognitive Behavioral Therapy for Generalized Anxiety Disorder: A Meta-Analysis of Randomized Control Trials. Cureus, 15(5), e39276. https://doi.org/10.7759/cureus.39252
Sequeda, G., Durán-Rondón, S., Acosta-López, J. E., Torres-Santos, E. A., & Rivera-Porras, D. (2026). Experiential Avoidance and Psychoactive Substance Use: Systematic Review. European Journal of Investigation in Health, Psychology and Education, 16(2), 22. https://doi.org/10.3390/ejihpe16020022
Song, X., Wang, X., Wang, X., Zhang, X., Zheng, Q., Zhang, X., & Lyu, S. (2026). The Relationship between Adolescent Experiential Avoidance and Smartphone Addiction: A Study Based on Latent Transition Analysis and Cross-Lagged Panel Network Analysis. Cyberpsychology, Behavior, and Social Networking, 29(5), 309-317. https://doi.org/10.1177/21522715261441401
Yalım, E., Mavi, C. Ü., & Özmenler, K. N. (2026). The Mediating Role of Rumination in the Relationship between Childhood Trauma and the Severity of Major Depressive Disorder. Psychiatry Investigation, 23(2), 242-250. https://doi.org/10.30773/pi.2025.0377
Zallar, L. J., & Dupont, M. B. (2026). Brain and Blood Biomarkers of Major Depressive Disorder: A Systematic Review. JAMA Psychiatry, 83(4), 312-325. https://doi.org/10.1001/jamapsychiatry.2025.4613
Zanini, C., Enrico, P., Pescuma, V., Favalli, V., Bressi, C., Brambilla, P., & Delvecchio, G. (2025). Assessing the Efficacy of Metacognitive Therapy as Monotherapy or Adjunctive Treatment in Patient Suffering from Major Depression and Dysthimia: A Comprehensive Review of Clinical Trials. Journal of affective disorders, 371, 333-343. https://doi.org/10.1016/j.jad.2024.11.050
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